Key result
Increased arterial stiffness was significantly associated with a higher prevalence of atrial fibrillation (OR 1.685), particularly in individuals with intermediate or high Framingham risk scores.
Why the study?
Arterial stiffness may predict the risk of atrial fibrillation, but this relationship has not been fully evaluated.
Is increased arterial stiffness associated with prevalent atrial fibrillation in a general screening population?
Cross-Sectional (n=8,048)
No
Is increased arterial stiffness associated with prevalent atrial fibrillation in a general screening population?
Odds Ratio: 1.685 (95% CI 1.098–2.588)
Absolute Event Rate: 2.2% vs 1%
p-value: p=0.017
Increased arterial stiffness is independently associated with prevalent atrial fibrillation in individuals with intermediate or high Framingham risk scores, suggesting CAVI could aid in AF risk stratification.
May aid AF risk stratification in intermediate/high Framingham patients; hypothesis-generating and leaves causal role open for prospective validation.
Atrial fibrillation (AF) is the most common arrhythmia in the elderly. Arterial stiffness may predict the risk of AF, but this relationship has not been fully evaluated. We assessed the association between arterial stiffness and prevalent AF. All subjects who had electrocardiography performed and a cardio-ankle vascular index (CAVI) calculated during a screening examination between 2010 and 2019 were enrolled. To evaluate the association between increased arterial stiffness and AF, we divided the population according to their Framingham risk score (FRS) into low-, intermediate-, and high-risk groups. A total of 8048 subjects were evaluated. The multivariate analysis revealed that increased arterial stiffness was significantly associated with AF prevalence, even after adjusting cardiovascular risk factors [odds ratio (OR) 1.685, 95% confidence interval (CI) 1.908-2.588, p = 0.017]. When we subcategorized the subjects according to their FRS, increased arterial stiffness was significantly associated with AF in the intermediate- and high-risk groups (OR 3.062, 95% CI 1.39-6.740 and OR3.877, 95% CI 1.142-13.167, respectively, BMI adjusted. High arterial stiffness shows a significant association with AF in those with intermediate or high cardiovascular risk, and can be used for further risk stratification of patients.
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Chung et al. (2021) conducted a cross-sectional in Atrial Fibrillation (n=8,048). Increased arterial stiffness (CAVI ≥ 8) vs. Normal arterial stiffness (CAVI < 8) was evaluated on Prevalent atrial fibrillation (OR 1.685, 95% CI 1.098-2.588, p=0.017). Increased arterial stiffness was significantly associated with a higher prevalence of atrial fibrillation (OR 1.685), particularly in individuals with intermediate or high Framingham risk scores.
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