Key result
The minor allele of the VEGF polymorphism rs3025039 was inversely associated with atherosclerosis among older Japanese adults with hypertension (OR 0.78).
Why the study?
Because VEGF contributes to angiogenesis and is inversely associated with the minor allele of rs3025039, this minor allele could be inversely associated with atherosclerosis in hypertension.
Is the minor allele of VEGF polymorphism rs3025039 associated with reduced atherosclerosis in older adults with hypertension?
Cross-Sectional (n=1,793)
No
Is the minor allele of VEGF polymorphism rs3025039 associated with reduced atherosclerosis in older adults with hypertension?
Odds Ratio: 0.78 (95% CI 0.64–0.96)
p-value: p=0.021
The minor allele of the angiogenesis-related VEGF polymorphism rs3025039 is inversely associated with atherosclerosis (CIMT ≥ 1.1 mm) among older Japanese individuals with hypertension.
Hypothesis-generating for VEGF rs3025039 in hypertensive atherosclerosis; prospective studies needed before clinical consideration.
Angiogenesis inhibition therapy causes hypertension by increasing peripheral vascular resistance. Vasa vasorum angiogenesis plays a crucial role in the development of atherosclerosis. Since vascular endothelial growth factor (VEGF), which contributes to the progress of angiogenesis, is reported to be inversely associated with the minor allele of polymorphism rs3025039, the minor allele of rs3025039 could be inversely associated with atherosclerosis among individuals with hypertension. A cross-sectional study of 1793 older Japanese adults aged 60-89 years with hypertension who participated in general health check-ups was conducted. Atherosclerosis was defined as carotid intima-media thickness (CIMT) ≥ 1.1 mm. The minor allele of polymorphism rs3025020 was positively associated with VEGF. Therefore, in addition to known cardiovascular risk factors, rs3025020 genotype acted as a confounding factor in the present study. Independent of known confounding factors, the minor allele of rs3025039 was inversely associated with atherosclerosis among older Japanese adults with hypertension. The fully adjusted odds ratio (OR) and 95% confidence interval (CI) for atherosclerosis with the minor allele of rs3025039 was 0.78 (0.64, 0.96). The angiogenesis-related polymorphism rs3025039 was associated with the development of atherosclerosis among older Japanese individuals. This study indicates that the development of atherosclerosis among older individuals might partly indicate a capacity for angiogenesis.
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Shimizu et al. (2022) conducted a cross-sectional in Hypertension and Atherosclerosis (n=1,793). VEGF polymorphism rs3025039 minor allele vs. Major allele (C/C genotype) was evaluated on Atherosclerosis (defined as carotid intima-media thickness ≥ 1.1 mm) (OR 0.78, 95% CI 0.64, 0.96, p=0.021). The minor allele of the VEGF polymorphism rs3025039 was inversely associated with atherosclerosis among older Japanese adults with hypertension (OR 0.78).
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