February 1, 1996Journal of Biological ChemistryOpen Access

A Splice Variant of the ITF-2 Transcript Encodes a Transcription Factor That Inhibits MyoD Activity

View Full Paper

Ask AI

Bookmark

Population

Nonmuscle cells transfected with cDNAs derived from alternatively spliced forms of mouse ITF-2

Design

Preclinical

Authors

ISIlona S. SkerjancUniversity of Ottawa JTJames TruongNewYork–Presbyterian Hospital PFPascale FilionUniversity of Ottawa

Discussion

Member takes

Implication

No clinical implications from this animal study; extends the spectrum of MyoD regulators in muscle gene transcription.

Structured PICO

Population

Nonmuscle cells transfected with cDNAs derived from alternatively spliced forms of mouse ITF-2 (MITF-2A and -2B)

Intervention

Transfection with MITF-2A or MITF-2B

Outcome

Transactivation of the cardiac alpha-actin promoter and inhibition of MyoD activationsurrogate

Differentially spliced transcripts of mouse ITF-2 encode proteins that can dimerize with MyoD to either activate or repress transcription of muscle-specific genes.

Cite This Study

Skerjanc et al. (1996) studied this question.

synapsesocial.com/papers/6a71b891c1a24a6142dbbd7f https://doi.org/10.1074/jbc.271.7.3555

View Full Paper

Ask AI

Bookmark

A Splice Variant of the ITF-2 Transcript Encodes a Transcription Factor That Inhibits MyoD Activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Splice Variant of the ITF-2 Transcript Encodes a Transcription Factor That Inhibits MyoD Activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider