July 14, 2003Molecular and Cellular BiologyOpen Access

Transcription Enhancer Factor 1 Binds Multiple Muscle MEF2 and A/T-Rich Elements during Fast-to-Slow Skeletal Muscle Fiber Type Transitions

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Structured PICO

Population

Adult mouse skeletal muscle (plantaris) and mouse C2C12 myotubes

Intervention

Mechanical overload (MOV) and transient coexpression of TEF proteins

Comparator

Basal conditions / control promoters

Outcome

Identification of betaA/T-rich binding factor and transcriptional activation of muscle promoterssurrogate

TEF proteins likely contribute to the regulation of skeletal, cardiac, and smooth muscle gene networks by binding select A/T-rich and MEF2 elements during hypertrophic conditions.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

No immediate clinical implications; leaves open TEF protein roles in hypertrophic gene regulation for further mechanistic studies.

Cite This Study

Karasseva et al. (2003) studied this question.

synapsesocial.com/papers/6a1a0c163f3ec013f0df69fb https://doi.org/10.1128/mcb.23.15.5143-5164.2003

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Transcription Enhancer Factor 1 Binds Multiple Muscle MEF2 and A/T-Rich Elements during Fast-to-Slow Skeletal Muscle Fiber Type Transitions

Structured PICO

Discussion

Implication

Cite This Study

Transcription Enhancer Factor 1 Binds Multiple Muscle MEF2 and A/T-Rich Elements during Fast-to-Slow Skeletal Muscle Fiber Type Transitions

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider