Key result
DTEF-1 is highly expressed early in chick embryogenesis and interacts with the cardiac troponin T promoter in vivo, independently or cooperatively trans-activating it in a tissue-specific manner.
DTEF-1 acts as an early marker of the myocardial phenotype, trans-activating the cardiac troponin T promoter during early chick embryogenesis.
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Identifies DTEF-1 as potential early myocardial marker in avian embryos; leaves open its role in mammalian cardiogenesis.
Azakie et al. (2005) studied Cardiac development. Divergent transcriptional enhancer factor-1 (DTEF-1) was evaluated on DTEF-1 expression and interaction with the cardiac troponin T promoter. DTEF-1 is highly expressed early in chick embryogenesis and interacts with the cardiac troponin T promoter in vivo, independently or cooperatively trans-activating it in a tissue-specific manner.
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