May 1, 1992Molecular and Cellular Biology

Identification and characterization of a cardiac-specific transcriptional regulatory element in the slow/cardiac troponin C gene.

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Population

Cardiac myocytes (in vitro and in vivo models)

Design

Preclinical

Authors

MPMichael S. ParmacekGeneral / Preventive / Lipids AVA VoraUniversity of Iowa TSTingliang ShenJersey City Medical Center

Discussion

Member takes

Implication

Critical cis-elements for cardiac cTnC enhancer function; leaves open their role in human disease or therapeutic modulation.

Structured PICO

Population

Cardiac myocytes (in vitro and in vivo models)

Intervention

Identification and mutation of cardiac-specific promoter and enhancer regions (bp -124 to +32) of the slow/cardiac troponin C (cTnC) gene

Outcome

cTnC gene expression and enhancer activitysurrogate

The study identifies a novel cardiac-specific promoter and enhancer regulating cTnC gene expression, demonstrating distinct transcriptional regulatory pathways in cardiac versus skeletal muscle.

Cite This Study

Parmacek et al. (1992) studied this question.

synapsesocial.com/papers/6a90db8c0fd3bacd29cae0df https://doi.org/10.1128/mcb.12.5.1967

View Full Paper

Ask AI

Bookmark

Identification and characterization of a cardiac-specific transcriptional regulatory element in the slow/cardiac troponin C gene.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification and characterization of a cardiac-specific transcriptional regulatory element in the slow/cardiac troponin C gene.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider