Population
Cell lines used to study human cardiac/slow-twitch troponin C gene regulation
Design
Preclinical
Authors
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Does not support clinical changes in cardiac gene regulation; leaves open translation of cell-type-specific enhancer cooperativity from animal models.
The human cardiac troponin C gene is regulated by distinct, cooperative, cell-type-specific elements in skeletal versus cardiac muscle cells.
Christensen et al. (1993) studied this question.
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