Key result
Palliative chemotherapy with anthracycline and ifosfamide was totally inactive in a 67-year-old man with metastatic angiosarcoma of the kidney following surgical removal.
Case Report (n=1)
Standard palliative chemotherapy with anthracycline and ifosfamide is inactive in metastatic renal angiosarcoma, highlighting the need for alternative approaches such as antiangiogenic agents.
This case cautions against anthracycline-ifosfamide in metastatic renal angiosarcoma; leaves open antiangiogenic approaches for prospective trials.
Angiosarcomas are rare soft tissue malignancies. Typically they originate from the skin of the scalp or face, whereas visceral sarcomas are very rare. We report the case of a 67-year-old man affected by a large angiosarcoma of the kidney. After surgical removal, a rapid peritoneal, visceral and cutaneous diffusion developed. Palliative chemotherapy, based on anthracycline and ifosfamide, which are normally used to treat all other high-grade spindle cell sarcomas, was totally inactive. On the basis of these results and of the biological characteristics of these rare neoplasms it is mandatory to develop other therapeutic approaches. Antiangiogenetic agents are of interest for this disease due to the peculiar origin of the cells of these sarcomas.
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Berretta et al. (2006) conducted a case report in Metastatic Angiosarcoma of the Kidney (n=1). Surgical removal and palliative chemotherapy (anthracycline and ifosfamide) was evaluated on Tumor response to chemotherapy. Palliative chemotherapy with anthracycline and ifosfamide was totally inactive in a 67-year-old man with metastatic angiosarcoma of the kidney following surgical removal.
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