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Transmission electron microscopy (TEM) can directly visualize sample of interest and combined with single particle averaging analysis can reveal more detailed, higher resolution feature of the sample. Cryo-electron microscopy (cryoEM) is a type of TEM to image frozen hydrated sample which allows scientists to study the specimens in their native states. Thus, cryo-EM has become a critical analysis tool in accelerating therapeutics and vaccine development in biopharma industry.
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Zheng et al. (2022) studied this question.
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