Key result
Muscadine grape seed supplementation did not significantly improve brachial flow-mediated dilation compared to placebo (4.6% vs 5.2%; P=0.25), but significantly increased resting brachial diameter.
Why the study?
Does muscadine grape seed supplementation improve endothelial function in adults with or at risk for cardiovascular disease?
RCT (n=50)
double-blind
randomized
Does muscadine grape seed supplementation improve endothelial function in adults with or at risk for cardiovascular disease?
Absolute Event Rate: 4.6% vs 5.2%
p-value: p=0.25
Muscadine grape seed supplementation for 4 weeks did not improve flow-mediated dilation but significantly increased resting brachial diameter in patients with or at risk for cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Does not improve endothelial function by flow-mediated dilation; challenges efficacy of muscadine grape seed supplementation in adults with cardiovascular risk.
Mellen et al. (2010) conducted an RCT in coronary disease or ≥1 cardiac risk factor (n=50). Muscadine grape seed supplementation vs. placebo was evaluated on brachial flow-mediated dilation (FMD) (p=0.25). Muscadine grape seed supplementation did not significantly improve brachial flow-mediated dilation compared to placebo (4.6% vs 5.2%; P=0.25), but significantly increased resting brachial diameter.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: