March 1, 1976American Journal of Physiology-Legacy Content

Electromyographic response of respiratory muscles during elastic loading

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Population

Anesthetized dogs

Comparison

Graded elastic loading and changes in PCO2… vs Unloaded breaths / intact vagus nerve

Design

Preclinical

Authors

SKS. G. KelsenCalifornia University of Pennsylvania MAMD AltoseCalifornia University of Pennsylvania NSNN StanleyCalifornia University of Pennsylvania

Discussion

Member takes

Implication

Vagal mediation of loaded breathing in dogs warrants caution against clinical extrapolation; leaves open human reflex mechanisms for targeted study.

Structured PICO

Population

Anesthetized dogs

Intervention

Graded elastic loading (applied for 1-20 breaths) and changes in PCO2 during CO2 rebreathing, with or without vagotomy or vagal cooling

Comparator

Unloaded breaths / intact vagus nerve

Outcome

Electromyogram (EMG) from the diaphragm (ED) and the intercostal muscle (EIC)surrogate

Elastic loading in anesthetized dogs elicits reflex increases in respiratory muscle EMG activity, mediated partly by the Hering-Breuer reflex and additional reflex components during subsequent breaths.

Cite This Study

Kelsen et al. (1976) studied this question.

synapsesocial.com/papers/6a71bf2887f92105712856d5 https://doi.org/10.1152/ajplegacy.1976.230.3.675

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Implication

Vagal mediation of loaded breathing in dogs warrants caution against clinical extrapolation; leaves open human reflex mechanisms for targeted study.

Electromyographic response of respiratory muscles during elastic loading

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electromyographic response of respiratory muscles during elastic loading

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider