Diabetes mellitus accelerates cardiovascular disease progression through interconnected epigenetic, genetic, and cellular signaling mechanisms involving hyperglycemia, inflammation, and dyslipidemia.
Diabetes mellitus elicits cellular, epigenetic, and post-translational changes that directly or indirectly affect the biology of the vasculature and other metabolic systems resulting in the apparition of cardiovascular disease. In this review, we provide a current perspective on the most recent discoveries in this field, with particular focus on hyperglycemia- induced pathology in the cardiovascular system. We also provide perspective on the clinical importance of molecular targeting of cardiovascular and diabetes mellitus therapies to treat hyperglycemia, inflammation, thrombosis, dyslipidemia, atherosclerosis, and hypertension.
Rodriguez‐Araujo et al. (Thu,) conducted a review in Cardiovascular disease in diabetes mellitus. Diabetes mellitus accelerates cardiovascular disease progression through interconnected epigenetic, genetic, and cellular signaling mechanisms involving hyperglycemia, inflammation, and dyslipidemia.