Key result
Depressed heart rate variability at admission to post-stroke rehabilitation was associated with increased cumulative functional disability at 4 weeks (70% vs 35%; adjusted OR 4.6, 95% CI 1.42-14.97).
Why the study?
Impaired autonomic nervous system regulation is frequently observed in stroke patients, but the impact of cardiac autonomic tone on functional outcome after early post-stroke rehabilitation remained to be evaluated.
Does depressed heart rate variability predict adverse functional outcomes in patients with subacute stroke undergoing early rehabilitation?
Cohort
Does depressed heart rate variability predict adverse functional outcomes in patients with subacute stroke undergoing early rehabilitation?
Odds Ratio: 4.6 (95% CI 1.42–14.97)
Absolute Event Rate: 70% vs 35%
p-value: p=<0.05
Depressed heart rate variability at admission for early post-stroke rehabilitation is a strong independent predictor of adverse functional outcomes and cumulative disability.
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May aid risk stratification in post-stroke rehabilitation; leaves open whether HRV modification improves functional outcomes.
Scherbakov et al. (2020) conducted a cohort in Subacute stroke (ischaemic and haemorrhagic). Depressed heart rate variability (HRV) vs. Normal HRV was evaluated on Cumulative functional disability (mRS ≥ 4, BI ≤ 70, and RMA ≤ 5) (OR 4.6, 95% CI 1.42-14.97, p=<0.05). Depressed heart rate variability at admission to post-stroke rehabilitation was associated with increased cumulative functional disability at 4 weeks (70% vs 35%; adjusted OR 4.6, 95% CI 1.42-14.97).
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