Key result
Overexpression of the Kif5b motor increased Kv1.5 current densities from 389 and 317 pA/pF to 614 and 580 pA/pF in HEK293 and H9c2 cells, demonstrating its essential role in anterograde trafficking.
Absolute Event Rate: 614% vs 389%
Kif5b is an essential motor for the anterograde trafficking of the cardiac voltage-gated potassium channel Kv1.5 to the cell surface.
No takes yet. Share an insight, caveat, or question.
Cell-based findings preclude clinical use; extends Kv1.5 trafficking mechanisms but leaves in vivo arrhythmia effects open.
Zadeh et al. (2009) studied this question. Kif5b overexpression vs. Control levels was evaluated on Kv1.5 current densities. Overexpression of the Kif5b motor increased Kv1.5 current densities from 389 and 317 pA/pF to 614 and 580 pA/pF in HEK293 and H9c2 cells, demonstrating its essential role in anterograde trafficking.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: