February 8, 2014Circulation ResearchOpen Access

Role for Myosin-V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes

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Population

Adult rat cardiomyocytes and cell models expressing Kv1.5

Comparison

Disruption of endogenous MYO5A and MYO5B motors… vs Control (non-disrupted motors)

Design

Preclinical

Authors

SSSarah M. SchumacherCleveland Clinic EVEileen VeselyJohnson & Johnson (United States)LZLian ZhangArmy Medical University

Discussion

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Implication

MYO5 motors regulate Kv1.5 trafficking in vitro; leaves open whether targeting them modulates atrial fibrillation in vivo.

Structured PICO

Population

Adult rat cardiomyocytes and cell models expressing Kv1.5

Intervention

Disruption of endogenous MYO5A and MYO5B motors using dominant negative constructs and short hairpin RNA silencing

Comparator

Control (non-disrupted motors)

Outcome

Cell surface density of Kv1.5 and IKur currentsurrogate

MYO5A and MYO5B control distinct steps in the surface trafficking of Kv1.5, identifying a potential cellular mechanism to target for the treatment of atrial fibrillation.

Cite This Study

Schumacher et al. (2014) studied this question.

synapsesocial.com/papers/6a7ac31eb2ad017e40323158 https://doi.org/10.1161/circresaha.114.302711

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Role for Myosin-V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role for Myosin-V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider