Effect of Ketofol instead of Propofol on hemodynamic stabilization for induction of Anesthesia in Laparatomy

Introduction: Hemodynamic alterations are a common complication during anesthetic induction with intravenous anesthesia. Hypotension due to propofol injection may be very severe in cardiac vascular patient. Ketamine produces the significant increasing but temporary in systematic blood stream, heartbeat, cardiac output through central sympathetic stimulation. Objective: To determine effect of ketofol and propofol for induction of anesthesia on hemodynamic changes during induction of anesthesia Methods: In a randomized cinical trial study 96 patient who were candidate for laparotomy enrolled and divided into two random group of propofol (48 person) and ketofol (48 person). Hemodynamic changes were recorded and examined after induction, after intubation and 5 and 10 minutes after intubation. Results: Heart rate was significantly variable in propofol group compare to ketofol group. Systolic, Diastolic, and mean arterial blood pressure was not significantly changed during time period of recording in ketofol group. However, blood pressure was significantly changed during the study in propofol group. Conclusion: ketofol is a proper alternative to propofol to stabilize heart rate and blood pressure in laparatomy.