Why the study?
Does ketamine/propofol admixture (ketofol) improve hemodynamic stability compared to propofol alone during induction of general anesthesia in ASA physical status I and II patients?
Population
American Society of Anesthesiology physical status I and II patients undergoing general anesthesia
Comparison
Ketamine/propofol admixture in a fixed-dose… vs Propofol alone during induction of general…
Design
RCT, randomly assigned, double-blinded, placebo-controlled
Follow-up
30 minutes
Authors
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Ketofol reduces post-induction hypotension versus propofol; confirms hemodynamic benefit in this RCT and supports trials in higher-risk patients.
Does ketamine/propofol admixture (ketofol) improve hemodynamic stability compared to propofol alone during induction of general anesthesia in ASA physical status I and II patients?
Ketofol (ketamine/propofol admixture) is associated with improved hemodynamic stability compared to propofol alone during the first 10 minutes of anesthesia induction.
Smischney et al. (2012) studied this question.
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