Key result
Ketofol induction provided better hemodynamic stability than propofol during the first 30 minutes, despite significantly increasing mean heart rate immediately and at 5 minutes (p=0.001 and p=0.022).
Why the study?
Propofol causes cardiorespiratory depression while ketamine increases heart rate and blood pressure, prompting evaluation of their combination (ketofol) for induction in elective surgical patients.
Does ketofol improve hemodynamic stability compared to propofol in adult elective surgical patients?
Population
62 elective surgical patients aged 18 to 65 years, ASA class I and II
Comparison
Ketofol vs propofol for induction of general anesthesia
Design
Double-blind randomized controlled trial
Follow-up
30 min
Authors
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Favors ketofol over propofol to limit induction hypotension; confirms stability advantage in elective surgical patients.
RCT (n=62)
Double-blind
randomly
No
Does ketofol improve hemodynamic stability compared to propofol in adult elective surgical patients?
p-value: p=<0.05
Ketofol induction provides better hemodynamic stability than propofol alone during the first 30 minutes of general anesthesia in elective surgical patients.
Hailu et al. (2021) conducted an RCT in elective surgical patients (n=62). Ketofol vs. Propofol was evaluated on change in systolic blood pressure, mean arterial pressure, and heart rate within 30mins (p=<0.05). Ketofol induction provided better hemodynamic stability than propofol during the first 30 minutes, despite significantly increasing mean heart rate immediately and at 5 minutes (p=0.001 and p=0.022).