Key result
Morbidly obese patients had significantly higher mean epicardial adipose tissue (5.09 vs 3.50) and extra-media thickness (808.50 vs 737.00) compared to controls (p<0.0001).
Why the study?
Increased values of emerging fat indices correlate with increased cardiovascular risk, prompting evaluation of novel non-invasive coronary disease predictors in morbid obesity.
Are emerging fat indices (EMT, PATIMA, EAT) increased in morbidly obese patients compared to controls?
Case-Control
Are emerging fat indices (EMT, PATIMA, EAT) increased in morbidly obese patients compared to controls?
Absolute Event Rate: 5.09% vs 3.5%
p-value: p=<0.0001
Novel non-invasive fat indices like epicardial adipose tissue and carotid extra-media thickness are significantly elevated in morbidly obese patients, suggesting increased cardiovascular risk independent of BMI.
May indicate heightened cardiovascular risk in morbid obesity; leaves open whether these measures improve risk stratification or outcomes.
INTRODUCTION: Increased values of emerging fat indices are correlated with increased cardiovascular risk. AIM: To examine the novel non-invasive predictors of coronary disease, namely the carotid extra-media thickness (EMT), PATIMA, and epicardial adipose tissue (EAT), in a group of patients with morbid obesity. MATERIAL AND METHODS: We examined a group of 40 morbidly obese (OB) patients and a control group (CG). All patients were subjected to anthropometric measurements, as well as laboratory and ultrasound examinations. RESULTS: EATmean and EMTmean differed significantly between groups (OB vs. CG): 5.09 vs. 3.50 and 808.50 vs. 737.00, p < 0.0001, respectively. CONCLUSIONS: Strong correlations were found between novel non-invasive predictors of coronary disease, namely the carotid extra-media thickness, PATIMA, and epicardial adipose tissue. The above-mentioned fat indices were not found to correlate significantly with BMI or other body weight-related parameters used to assess the adipose tissue content. Further studies are required.
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Domienik‐Karłowicz et al. (2019) conducted a case-control in Morbid obesity. Morbid obesity vs. Control group was evaluated on Mean epicardial adipose tissue (EATmean) (p=<0.0001). Morbidly obese patients had significantly higher mean epicardial adipose tissue (5.09 vs 3.50) and extra-media thickness (808.50 vs 737.00) compared to controls (p<0.0001).
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