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August 2, 2017Journal of the American Heart AssociationOpen Access

Association of Epicardial Adipose Tissue and High‐Risk Plaque Characteristics: A Systematic Review and Meta‐Analysis

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Why the study?

Is epicardial adipose tissue (EAT) associated with the presence of high-risk plaque (HRP)?

Structured PICO

Is epicardial adipose tissue (EAT) associated with the presence of high-risk plaque (HRP)?

P

Population

9 studies (n=3772 patients) reporting high-risk plaque (HRP) by computed tomography or intracoronary imaging and measuring epicardial adipose tissue (EAT) by volumetric assessment (EAT-v) or linear thickness (EAT-t).

I

Intervention

Epicardial adipose tissue (EAT) measured by volumetric assessment (EAT-v) or linear thickness (EAT-t)

O

Outcome

Presence of high-risk plaque (HRP)surrogate

Increased epicardial adipose tissue volume is significantly associated with the presence of high-risk atherosclerotic plaques on imaging.

Limitations

larger scale study is still required

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

EAT assessment may refine HRP risk stratification in CT imaging; leaves open whether volumetric measurement improves outcomes over standard approaches.

Cite This Study

Nerlekar et al. (2017) studied this question.

synapsesocial.com/papers/6a70c5815671bbf00bc2c483 https://doi.org/10.1161/jaha.117.006379

Topics

Coronary artery disease Coronary CT angiography

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Epicardial Adipose Tissue Accumulation Is Associated With Renal Dysfunction and Coronary Plaque Morphology on Multidetector Computed Tomographycross-sectional · 2015 · 34 citations
2Lack of Association Between Epicardial Fat Volume and Extent of Coronary Artery Calcification, Severity of Coronary Artery Disease, or Presence of Myocardial Perfusion Abnormalities in a Diverse, Symptomatic Patient Populationcross-sectional · 2015 · 86 citations
3Epicardial and Perivascular Adipose Tissues and Their Influence on Cardiovascular Disease: Basic Mechanisms and Clinical Associationsreview · 2014 · 344 citations
4Interleukin-1β Regulates Fat-Liver Crosstalk in Obesity by Auto-Paracrine Modulation of Adipose Tissue Inflammation and ExpandabilityOriginal Research · 2013 · 148 citations
5Plaque Characterization by Coronary Computed Tomography Angiography and the Likelihood of Acute Coronary Events in Mid-Term Follow-Upcohort · 2015 · 835 citations