Key result
Patients with coronary artery disease had higher epicardial adipose tissue thickness compared to non-CAD patients.
Why the study?
The authors sought to systematically evaluate the efficacy and diagnostic value of epicardial adipose tissue in coronary artery disease.
Does epicardial adipose tissue thickness measured by echocardiography or CT correlate with the presence of coronary artery disease?
Meta-Analysis (n=4,049)
Does epicardial adipose tissue thickness measured by echocardiography or CT correlate with the presence of coronary artery disease?
Epicardial adipose tissue thickness is significantly increased in patients with coronary artery disease, suggesting it may serve as a useful non-invasive imaging biomarker for CAD diagnosis and risk stratification.
Answers are grounded in this paper and cite their sources.
Epicardial adipose tissue thickness may aid CAD detection; leaves open its incremental value over standard risk factors.
Objective: To systematically evaluate the efficacy and diagnostic value of epicardial adipose tissue in coronary artery disease. Methods: The authors searched PubMed, Embase, Web of Science, CNKI and CBM from the database to January 2019, and collected articles on the clinical trials of epicardial adipose tissue in coronary heart disease. The improved Jadad scale was used for quality evaluation, and Revman 5.3 software was used for metaanalysis of the included literature. Results: Finally, 21 articles were included, including a total of 4049 patients. EAT was 12.21 2.62 mm in the CAD group and 9.92 1.37 mm in the non-CAD group. EAT was 2.22 1.86 mm in the CAD group and 1.8 1.4 mm in the non-CAD group. The random effect model was adopted for the study (I2=95%, p<0.00001, Q=398.94, df [Q]=20), and heterogeneity was found in all cases. The EAT of CAD patients was significantly higher than that of non-CAD patients (SMD=1.07, 95% CI=0.75-1.38, p<0.00001). EAT of CAD patients in echocardiography group and CT measurement group was higher than that of non-CAD patients. Conclusion: According to the results of this meta-analysis, EAT in patients undergoing echocardiography or CT examination has certain value in the diagnosis and risk stratification of coronary artery disease due to its ease-of-use, cost-effectiveness and non-exposure characteristics, and is worthy of further clinical exploration.
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Yuan et al. (2019) conducted a meta-analysis in Coronary artery disease (n=4,049). Coronary artery disease (CAD) vs. Without coronary artery disease (non-CAD) was evaluated on Epicardial adipose tissue (EAT) thickness (SMD 1.07, 95% CI 0.75-1.38, p=<0.00001). Patients with coronary artery disease had higher epicardial adipose tissue thickness compared to non-CAD patients.
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