Key result
Epicardial adipose tissue thickness was significantly higher in patients with coronary artery disease compared to those without (MD 1.57 mm; 95% CI 0.74-2.40; P<0.00001).
Why the study?
Is epicardial adipose tissue thickness and volume associated with the presence of coronary artery disease?
Population
2,872 patients from 15 case-control studies and 1 cross-sectional study evaluated for coronary artery disease.
Comparison
Higher epicardial adipose tissue thickness and… vs Lower EAT thickness and volume / non-CAD patients
Design
Meta-analysis
Authors
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Does not support routine EAT measurement in CAD evaluation; leaves open its diagnostic role pending prospective validation.
Meta-Analysis (n=2,872)
Is epicardial adipose tissue thickness and volume associated with the presence of coronary artery disease?
Mean Difference: 1.57 (95% CI 0.74–2.4)
p-value: p=<0.00001
Epicardial adipose tissue thickness and volume are significantly increased in patients with coronary artery disease, suggesting its potential utility as a predictive marker.
Xu et al. (2012) conducted a meta-analysis in Coronary artery disease (n=2,872). Epicardial adipose tissue (EAT) vs. Non-CAD group was evaluated on EAT thickness (MD 1.57, 95% CI 0.74, 2.40, p=<0.00001). Epicardial adipose tissue thickness was significantly higher in patients with coronary artery disease compared to those without (MD 1.57 mm; 95% CI 0.74-2.40; P<0.00001).