Key result
In asymptomatic, nonhypertensive, and nondiabetic subjects, the presence of microalbuminuria was independently associated with a more than threefold increased odds of significant coronary artery stenosis (OR 3.397).
Why the study?
Is microalbuminuria associated with subclinical coronary atherosclerosis in asymptomatic nonhypertensive, nondiabetic subjects?
Cross-Sectional (n=1,318)
No
Is microalbuminuria associated with subclinical coronary atherosclerosis in asymptomatic nonhypertensive, nondiabetic subjects?
Odds Ratio: 3.397 (95% CI 1.138–10.14)
Absolute Event Rate: 11.5% vs 4.9%
p-value: p=0.028
Microalbuminuria is an independent marker of subclinical coronary atherosclerosis even in asymptomatic individuals without hypertension or diabetes.
May support microalbuminuria in subclinical CAD risk assessment; hypothesis-generating and should not yet change practice.
We aimed to investigate the significance of microalbuminuria and its relationship with subclinical atherosclerosis in nonhypertensive and nondiabetic patients, by using coronary artery computed tomography (CT). A total of 1,318 nonhypertensive and nondiabetic subjects who had taken coronary artery CT and measured spot urine albumin to creatinine ratio (UACR) were evaluated. The atherosclerotic changes of coronary arteries were greater in subjects with microalbuminuria, reflected by coronary artery calcium score (CACS) and significant coronary artery stenosis (CACS ≥ 100 in 15.3% vs 7.6% and stenosis ≥ 50% in 11.5% vs 4.9% of patients with vs without microalbuminuria, P = 0.008 and P = 0.011, respectively). Among various parameters that are known as a risk factor or possible biomarkers of coronary artery disease, presence of microalbuminuria, age and Framingham risk score were significantly related to coronary artery stenosis. Among them the presence of microalbuminuria showed stronger correlation than others to the coronary artery stenosis detected by CT, even after adjusting confounding factors (OR 3.397, 95% confidence interval 1.138 to 10.140, P = 0.028). The presence of microalbuminuria by UACR was significantly associated with presence of coronary artery stenosis ≥ 50% in asymptomatic, nonhypertensive and nondiabetic general population. Our study suggests that the presence of microalbuminuria may imply subclinical coronary artery disease, even in asymptomatic population.
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Park et al. (2013) conducted a cross-sectional in Subclinical Coronary Atherosclerosis (n=1,318). Microalbuminuria vs. No microalbuminuria was evaluated on Significant coronary artery stenosis (≥ 50%) detected by CT (OR 3.397, 95% CI 1.138-10.140, p=0.028). In asymptomatic, nonhypertensive, and nondiabetic subjects, the presence of microalbuminuria was independently associated with a more than threefold increased odds of significant coronary artery stenosis (OR 3.397).
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