To Estimate the Prevalence of Microalbuminuria in Non-Diabetic Patients With Coronary Artery Disease (Cad)

BACKGROUNDNew WHO report Global atlas on cardiovascular disease prevention and control, 19 September 2011, states that coronary artery disease is the leading cause of death and disability in the world.Microalbuminuria may be a marker of generalised vascular disease with Arterial Endothelial Dysfunction being involved in the pathogenesis of atherothrombotic vascular disease.(1,2) Albumin is increasingly recognised as the earliest sign of vascular damage in both the kidney and the heart.Microalbuminuria may be a marker of generalised vascular disease with arterial endothelial dysfunction being involved in the pathogenesis of atherothrombotic vascular disease.Studies have shown Microalbuminuria is positively associated with Ischaemic Heart Disease (3) in non-diabetic subjects and can be regarded as an important additional risk factor for Ischaemic Heart Disease.Microalbuminuria is an important cardiovascular and mortality risk factor, (4) irrespective of diabetes or hypertension.(5) Microalbuminuria seems to reflect a state of pathophysiologic vascular dysfunction that makes an individual susceptible to organ damage. MATERIALS AND METHODS Cross-sectional hospital-based study.Sample Size-Convenient sampling method was used till 60 study subjects were included.Sixty non-diabetic subjects of both sexes with coronary artery disease admitted as inpatients in Rajeev Gandhi Institute of Medical Sciences Hospital and Research Institute during the study period between May 2014 and July 2015 were included. RESULTSIn this study, the prevalence of Microalbuminuria among CAD patients without Diabetes mellitus is 88.3% with high statistical significance in the age group of 30 -60 yrs.(40%) followed by more than 60 yrs.(30%), 41 -50 yrs.(20%) and less than 40 yrs.(10%).This suggests that CAD is more common after 50 yrs. of age.The mean age is 55.13 + 9.95 yrs. CONCLUSIONIn this study, majority of subjects were males (78.3%) and (21.7%) were females.This observation was statistically significant.66.7% of CAD subjects had positive family history of CAD.This observation was statistically significant.58.3% had smoking history.In this study, 61.7% of subjects presented with prevalence of Microalbuminuria.Among CAD patients without diabetes was 88.3%.This observation was statistically significant.Mean microalbumin levels was 56.9 + 30.4 mg.There was significant association between smoking and microalbuminuria among CAD subjects in the study.