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March 30, 1984Science

Increased Phosphorylation of Myosin Light Chain Kinase After an Increase in Cyclic AMP in Intact Smooth Muscle

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Authors

PLPrimal de LanerolleUniversity of Illinois Chicago MNMasakatsu NishikawaMie University Hospital DYDavid A. YostNational Institutes of Health

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Implication

MLCK phosphorylation mediates cAMP relaxation in smooth muscle; extends basic mechanisms but leaves clinical translation open.

Key Points

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Cite This Study

Lanerolle et al. (1984) studied this question.

synapsesocial.com/papers/6a71c687660549caf2c643fe https://doi.org/10.1126/science.6322302

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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

1Role of Ca2+ and myosin light chain phosphorylation in regulation of smooth muscle1982 · 170 citations
2Myosin phosphorylation during contraction and relaxation of tracheal smooth muscle.1980 · 104 citations
3Characterization of antibodies to smooth muscle myosin kinase and their use in localizing myosin kinase in nonmuscle cells.1981 · 89 citations