April 1, 1987Angiology
Systolic Hypertension in Patients with Arteriosclerosis Obliterans of the Lower Limbs
Why the study?
Are atherosclerotic modifications in patients with arteriosclerosis obliterans of the lower limbs associated with changes in blood pressure and arterial compliance compared to controls?
Population
20 patients with arteriosclerosis obliterans of the lower limbs (AOD) and 10 age- and sex-matched controls
Design
Case-control
Authors
Discussion
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Member takes
Implication
Alerts clinicians to widened pulse pressure in AOD; leaves open whether compliance reduction warrants targeted intervention or predicts outcomes.
Key Points
- To evaluate hemodynamic changes, arterial compliance, and pulse wave velocity in patients diagnosed with arteriosclerosis obliterans of the lower limbs.
- Measured intraarterial blood pressure, brachial artery compliance, arterial diameter, and pulse wave velocity in 20 patients with arteriosclerosis obliterans of the lower limbs (AOD).
- Compared hemodynamic and vascular parameters against 10 age- and sex-matched control participants.
- Patients with AOD exhibited significantly higher systolic pressure and lower diastolic pressure than controls despite identical mean arterial pressure, producing a significantly increased pulse pressure.
- Brachial artery compliance was significantly reduced in AOD patients and negatively correlated with pulse pressure, whereas brachial artery diameter and pulse wave velocity remained within normal ranges.
Structured PICO
Are atherosclerotic modifications in patients with arteriosclerosis obliterans of the lower limbs associated with changes in blood pressure and arterial compliance compared to controls?
P
Population
20 patients with arteriosclerosis obliterans of the lower limbs (AOD) and 10 age- and sex-matched controls
C
Comparator
10 age- and sex-matched controls
O
Outcome
Intraarterial blood pressure, brachial artery compliance and diameter, and pulse wave velocitysurrogate
In patients with arteriosclerosis obliterans of the lower limbs, increased pulse pressure is related to decreased arterial compliance, reflecting intrinsic modifications of the viscoelastic properties of the arterial wall.
Cite This Study
Safar et al. (1987) studied this question.