Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1982Anesthesia & Analgesia

A Controlled Comparison of the Effects of Extradural Diamorphine and Bupivacaine on Plasma Glucose and Plasma Cortisol in Postoperative Patients

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does extradural diamorphine reduce postoperative plasma glucose and cortisol levels compared to extradural bupivacaine in fit women undergoing major gynecologic operations?

Population

20 fit women undergoing major gynecologic operations with morphine premedication and extradural local…

Comparison

5 mg of extradural diamorphine given after surgery vs Further extradural local anesthetic given after…

Design

Other

Follow-up

postoperative

Authors

MCMichael J. CowenMilton Keynes HospitalRBRoy BullinghamRoyal Free London NHS Foundation TrustGPGordon M. C Paterson

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for neuraxial opioid attenuation of surgical stress; prospective trials needed before clinical adoption.

Structured PICO

Does extradural diamorphine reduce postoperative plasma glucose and cortisol levels compared to extradural bupivacaine in fit women undergoing major gynecologic operations?

P
Population
20 fit women undergoing major gynecologic operations with morphine premedication and extradural local anesthetic with nitrous oxide, oxygen, and halothane
I
Intervention
5 mg of extradural diamorphine given after surgery
C
Comparator
Further extradural local anesthetic (bupivacaine) given after surgery
O
Outcome
Postoperative responses of plasma glucose and cortisol levelssurrogate

A small dose of extradural diamorphine significantly suppresses the postoperative metabolic stress response (glucose and cortisol) compared to extradural bupivacaine, suggesting a local action at the spinal cord.

Cite This Study

Cowen et al. (1982) studied this question.

synapsesocial.com/papers/6a71c7e2ce524a4339c523f6https://doi.org/10.1213/00000539-198201000-00004
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of extradural and intravenous diamorphine as a supplement to extradural bupivacaine1991 · 10 citations
  2. 2Comparative Analysis of Epidural Dexamethasone and Epidural Morphine (EM) for Postoperative Pain Control After Total Abdominal Hysterectomy: A Randomized Clinical Trial2024
  3. 3Suppression of perioperative stress response in elective abdominal surgery: A randomized comparison between dexmedetomidine and epidural block2022 · 7 citations
  4. 4Extradural Morphine for Pain after Surgery1982
  5. 5Effect of varying doses of intrathecal dexmedetomidine combined with hyperbaric bupivacaine on postoperative analgesia in patients undergoing infraumbilical abdominal surgeries2026