Key result
In young male patients with arterial hypertension, the NO/ET-1 index was significantly reduced compared to healthy controls (1.96 vs 6.24, p<0.001), reflecting progressive endothelial dysfunction.
Why the study?
Do endothelial biomarkers (NO and ET-1) and their ratio differ between young male patients with arterial hypertension and healthy controls?
Cross-Sectional (n=97)
No
Do endothelial biomarkers (NO and ET-1) and their ratio differ between young male patients with arterial hypertension and healthy controls?
Absolute Event Rate: 1.96% vs 6.24%
p-value: p=<0.001
In young male patients with arterial hypertension, a decreased NO/ET-1 ratio indicates endothelial dysfunction and may serve as a prognostic marker for an unfavorable clinical course.
May support endothelial biomarker monitoring in young hypertensive males; hypothesis-generating and should not change practice without prospective validation.
Objective. To defi ne the endothelial vasoactive substances (nitric oxide, NO; and endothelin-1, ET-1), characterizing endothelial function in young patients with arterial hypertension (АH) and to identify the diagnostically signifi cant biomarkers of the endothelial function and their prognostic value for assessment of AH at initial stages in young patients. Design and methods. 65 male patients with AH (age 20-45 years old), with the level of total cholesterol < 5,0 mmol/l and blood pressure < 160/100 mmHg; and 32 healthy volunteers (mean age - 32,8 4,9 years) were enrolled. Results. Endotelial biomarkers (NO and ET-1), characterizing the ratio vasoconstrictor agent (ET-1)/vasodilator (NO) in young patients with AH can be considered to be a potential prognostic marker of unfavourable course of AH especially at initial stages.
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Lyamina et al. (2010) conducted a cross-sectional in Arterial hypertension (n=97). Arterial hypertension vs. Healthy volunteers was evaluated on Ratio of stable NO metabolites to endothelin-1 (NO/ET-1 index) (p=<0.001). In young male patients with arterial hypertension, the NO/ET-1 index was significantly reduced compared to healthy controls (1.96 vs 6.24, p<0.001), reflecting progressive endothelial dysfunction.
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