What is the clinical evidence from this study?

Study design: Cohort. Population: Hypertension and Chronic Kidney Disease (n=398). Intervention: Healthy status vs. Chronic kidney disease. Primary outcome: Development of hypertension (HR 0.2, p=<.001).

What question did this study set out to answer?

To determine whether systolic blood pressure increases with age in cats independently of chronic kidney disease and to identify risk factors associated with developing hypertension.

April 27, 2015Journal of Veterinary Internal MedicineOpen Access

Changes in Systolic Blood Pressure over Time in Healthy Cats and Cats with Chronic Kidney Disease

Q: What are the key findings of this study?

Systolic blood pressure increased with age in all cats, but healthy cats were at significantly lower risk of developing hypertension than those with chronic kidney disease (HR 0.2, P<0.001).

Q: What question did this study set out to answer?

To determine whether systolic blood pressure increases with age in cats independently of chronic kidney disease and to identify risk factors associated with developing hypertension.

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Key result

Systolic blood pressure increased with age in all cats, but healthy cats were at significantly lower risk of developing hypertension than those with chronic kidney disease (HR 0.2, P<0.001).

Why the study?

Does systolic blood pressure increase with age in cats, and is this independent of chronic kidney disease?

Population

398 cats ≥9 years old, comprising 265 cats with chronic kidney disease (CKD) and 133 healthy cats.

Design

Cohort

Authors

EBEsther Bijsmans RJRosanne E. JepsonUniversity of London YCYu‐Mei ChangRoyal Veterinary College

Discussion

Member takes

Overview

May warrant closer BP monitoring in cats with CKD; leaves open whether intervention alters outcomes.

Key Points

To determine whether systolic blood pressure increases with age in cats independently of chronic kidney disease and to identify risk factors associated with developing hypertension.
Retrospectively evaluated 265 cats with chronic kidney disease (CKD) and 133 healthy cats aged ≥9 years.
Categorized cats into four cohorts based on baseline renal status and longitudinal blood pressure: Healthy-normotensive, Healthy-developed hypertension, CKD-normotensive, and CKD-developed hypertension.
Compared systolic blood pressure (SBP) trajectory slopes over time and modeled clinical and biochemical risk factors for hypertension.
Excluding 105 cats that were hypertensive at initial CKD diagnosis, hypertension developed in 27 cats with CKD and 9 healthy cats after ≥3 months of follow-up.
Systolic blood pressure significantly increased with advancing age across all evaluated cats (P < .001).
Healthy cats experienced a significantly lower risk of developing hypertension compared to cats with CKD (HR 0.2, P < .001), with serum creatinine identified as an independent risk factor.

Study Design

Type

Cohort (n=398)

Structured PICO

Does systolic blood pressure increase with age in cats, and is this independent of chronic kidney disease?

Population

398 cats (265 with chronic kidney disease and 133 healthy cats aged ≥9 years) retrospectively evaluated for changes in systolic blood pressure and development of hypertension.

Comparator

Healthy cats compared to cats with chronic kidney disease

Outcome

Systolic blood pressure (SBP) over time slopes and development of hypertensionsurrogate

Main Result

Hazard Ratio: 0.2

Absolute Event Rate: 6.8% vs 16.9%

p-value: p=<.001

Systolic blood pressure increases with age in older cats, and the presence of chronic kidney disease significantly increases the risk of developing hypertension.

Cite This Study

Bijsmans et al. (2015) conducted a cohort in Hypertension and Chronic Kidney Disease (n=398). Healthy status vs. Chronic kidney disease was evaluated on Development of hypertension (HR 0.2, p=<.001). Systolic blood pressure increased with age in all cats, but healthy cats were at significantly lower risk of developing hypertension than those with chronic kidney disease (HR 0.2, P<0.001).

synapsesocial.com/papers/6a71cdb6c92390ac2d080315 https://doi.org/10.1111/jvim.12600

Topics

Hypertension management

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April 27, 2015Journal of Veterinary Internal MedicineOpen Access

Changes in Systolic Blood Pressure over Time in Healthy Cats and Cats with Chronic Kidney Disease

View Full Paper

Ask AI

Bookmark

Key result

Systolic blood pressure increased with age in all cats, but healthy cats were at significantly lower risk of developing hypertension than those with chronic kidney disease (HR 0.2, P<0.001).

Why the study?

Does systolic blood pressure increase with age in cats, and is this independent of chronic kidney disease?

Population

398 cats ≥9 years old, comprising 265 cats with chronic kidney disease (CKD) and 133 healthy cats.

Design

Cohort

Authors

EBEsther Bijsmans RJRosanne E. JepsonUniversity of London YCYu‐Mei ChangRoyal Veterinary College

Discussion

Member takes

Overview

May warrant closer BP monitoring in cats with CKD; leaves open whether intervention alters outcomes.

Key Points

To determine whether systolic blood pressure increases with age in cats independently of chronic kidney disease and to identify risk factors associated with developing hypertension.
Retrospectively evaluated 265 cats with chronic kidney disease (CKD) and 133 healthy cats aged ≥9 years.
Categorized cats into four cohorts based on baseline renal status and longitudinal blood pressure: Healthy-normotensive, Healthy-developed hypertension, CKD-normotensive, and CKD-developed hypertension.
Compared systolic blood pressure (SBP) trajectory slopes over time and modeled clinical and biochemical risk factors for hypertension.
Excluding 105 cats that were hypertensive at initial CKD diagnosis, hypertension developed in 27 cats with CKD and 9 healthy cats after ≥3 months of follow-up.
Systolic blood pressure significantly increased with advancing age across all evaluated cats (P < .001).
Healthy cats experienced a significantly lower risk of developing hypertension compared to cats with CKD (HR 0.2, P < .001), with serum creatinine identified as an independent risk factor.

Study Design

Type

Cohort (n=398)

Structured PICO

Does systolic blood pressure increase with age in cats, and is this independent of chronic kidney disease?

Population

398 cats (265 with chronic kidney disease and 133 healthy cats aged ≥9 years) retrospectively evaluated for changes in systolic blood pressure and development of hypertension.

Comparator

Healthy cats compared to cats with chronic kidney disease

Outcome

Systolic blood pressure (SBP) over time slopes and development of hypertensionsurrogate

Main Result

Hazard Ratio: 0.2

Absolute Event Rate: 6.8% vs 16.9%

p-value: p=<.001

Systolic blood pressure increases with age in older cats, and the presence of chronic kidney disease significantly increases the risk of developing hypertension.

Cite This Study

synapsesocial.com/papers/6a71cdb6c92390ac2d080315 https://doi.org/10.1111/jvim.12600

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Hypertension management

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