Why the study?
Does bradykinin B2 receptor activation reduce renal tubulointerstitial fibrosis in animal models of unilateral ureteral obstruction?
Population
B2-/- mice, C57Bl/6J control mice, transgenic rats overexpressing human tissue kallikrein gene TGR, and…
Comparison
Genetic ablation of bradykinin B2 receptor… vs Wild-type controls or saline treatment.
Design
Preclinical, Analyses were performed by an operator unaware of the origin of…
Follow-up
3 hours to 14 days (primarily 5 days)
Authors
Loading...
B2 activation may limit fibrosis in this model; leaves open translation to human CKD therapies.
Does bradykinin B2 receptor activation reduce renal tubulointerstitial fibrosis in animal models of unilateral ureteral obstruction?
In vivo activation of the bradykinin B2 receptor reduces renal tubulointerstitial fibrosis by increasing extracellular matrix degradation, providing mechanistic insight into the renal protective effects of ACE inhibitors.
Schanstra et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: