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July 1, 1979Circulation ResearchOpen Access

Neither dorsal root nor baroreceptor afferents are necessary for eliciting the renal responses to acute intravascular volume expansion in the primate Macaca fascicularis.

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Population

Nonhuman primate, Macaca fascicularis

Comparison

Acute isotonic, isooncotic intravascular volume… vs Intact neural pathways

Design

Preclinical

Authors

JGJ. P. GilmoreUniversity of Nebraska at OmahaTPT. V. PetersonUniversity of Nebraska at OmahaIZI H ZuckerUniversity of Nebraska Medical Center

Discussion

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Implication

These neural pathways are dispensable for hypervolemic natriuresis in primates; leaves open identification of primary mechanisms.

Structured PICO

P
Population
Nonhuman primate, Macaca fascicularis
I
Intervention
Acute isotonic, isooncotic intravascular volume expansion (15% of estimated blood volume) combined with dorsal rhizotomy (C6-T7) or vagotomy and sino-aortic denervation
C
Comparator
Intact neural pathways
O
Outcome
Renal responses (natriuresis and diuresis)surrogate

Dorsal root and baroreceptor afferents are not necessary for eliciting renal responses to hypervolemia in nonhuman primates.

Cite This Study

Gilmore et al. (1979) studied this question.

synapsesocial.com/papers/6a71d1b331a3df824329d35bhttps://doi.org/10.1161/01.res.45.1.95
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contribution of Intravascular Receptors to the Renal Responses Following Intravascular Volume Expansion1965 · 16 citations
  2. 2Atrial receptors and renal function1975 · 140 citations
  3. 3Unmyelinated fibres in the sacral 3 and caudal 1 ventral roots of the cat.1976 · 100 citations
  4. 4MECHANISMS OF THE RENAL RESPONSE TO PLASMA VOLUME EXPANSION1959 · 8 citations