Population
Canine skeletal muscle model
Comparison
3-min ischemia, rhythmical contractions, and… vs Rest (baseline)
Design
Preclinical
Authors
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May link adenosine/AMP to muscle ischemia and contraction responses; leaves open translation to human cardiovascular settings.
In a canine model, skeletal muscle releases increased amounts of adenosine and AMP during ischemia and contractions compared to rest.
Tominaga et al. (1973) studied this question.
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