Key result
Each one-millimeter increase in periprostatic fat thickness measured on multiparametric MRI was associated with an 8.9-fold increased odds of detecting high-grade prostate cancer (Gleason score ≥7).
Why the study?
The study was conducted to evaluate the relationship between periprostatic and subcutaneous fat thickness on MRI and Gleason scores.
Does periprostatic fat thickness measured on MRI predict prostate cancer aggressiveness in patients undergoing MRI-fusion biopsy?
Observational (n=51)
No
Does periprostatic fat thickness measured on MRI predict prostate cancer aggressiveness in patients undergoing MRI-fusion biopsy?
Odds Ratio: 8.941 (95% CI 1.9–41)
p-value: p=0.005
Periprostatic fat thickness measured on multiparametric MRI is an independent predictor of high-grade prostate cancer and can help foresee cancer aggressiveness before biopsy.
Objective: In this study, the relationship between periprostatic and subcutaneous fat thickness on magnetic resonans imaging (MRI) and Gleason scores (GS) was retrospectively evaluated.Materials and Methods: Fifty-one patients who underwent MRI before application of MRI fusion biyopsies were included 63, 578,5 (45-88) years in this study.On midsagittal T2-weighted images, the thickness of subcutaneous and periprostatic fat was calculated as the vertical distance from the pubic symphysis both to the skin and to the prostate, respectively.Results: The mean subcutaneous fat thickness (SCFT) and periprostatic fat thickness (PPFT) were 17.3813.02mm and 5.643.89mm, respectively.A positive correlation was found between GS and PPFT (p<0.001),SCFT (p<0.001),body mass index (BMI) (p<0.001),prostate spesific antigen (PSA) (p=0.002) and PSA density (p<0.001).In multivariate analysis, only PPFT was found to be statistically significant in predicting GS 7 (p=0.005).It has been shown that the risk of detecting GS 7 prostate cancer increases 8.9 times with one mm increase in PPFT values.Conclusion: Periprostatic fat tissue thickness can be used as an independent predictive factor in foreseeing prostate cancer aggressiveness before application of biopsy or radical prostatectomy.
No takes yet. Share an insight, caveat, or question.
Sökmen et al. (2023) conducted an observational in Prostate Cancer (n=51). Periprostatic fat thickness (PPFT) was evaluated on High-grade prostate cancer (Gleason score ≥7) (OR 8.941, 95% CI 1.9-41, p=0.005). Each one-millimeter increase in periprostatic fat thickness measured on multiparametric MRI was associated with an 8.9-fold increased odds of detecting high-grade prostate cancer (Gleason score ≥7).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: