Key result
Echocardiographic parameters including lateral E/Ea ≥ 12, LAVI ≥ 34 mL/m2, and Ard-Ad > 30 msec demonstrated strong diagnostic value and positive correlation with invasively measured left ventricular end-diastolic pressure in patients with HFpEF.
Why the study?
Invasive monitoring accurately estimates diastolic dysfunction but carries risk, prompting evaluation of standardized correlations between invasive and non-invasive parameters.
Do non-invasive echocardiographic diastolic parameters accurately correlate with invasively measured LVEDP in patients with HFpEF?
Observational (n=500)
No
Do non-invasive echocardiographic diastolic parameters accurately correlate with invasively measured LVEDP in patients with HFpEF?
Effect estimate: r = 0.77
p-value: p=<0.001
Lateral E/Ea ≥ 12, LAVI ≥ 34 mL/m2, and Ard-Ad > 30 msec are reliable non-invasive echocardiographic parameters that correlate well with invasively measured LVEDP for diagnosing diastolic dysfunction in HFpEF.
Observational correlation between echo parameters and invasive LVEDP remains uncertain; leaves open whether noninvasive assessment can guide diastolic dysfunction management.
OBJECTIVES: Though invasive monitoring is the most accurate to estimate diastolic dysfunction but it has its own risk. The purpose of this study was to find out any standardized correlation between invasive and non -invasive parameters. METHODS: It is an observational, descriptive study comprising of a total of 500 patients. The primary objective of the study was to determine the correlation between echocardiographic diastolic parameters and invasively measured left ventricular end diastolic pressure (LVEDP). RESULTS: On studying correlation of different invasive and non-invasive data it was reported that there was a weak correlation between peak E velocity (r = 0.14, p = 0.631), Peak A velocity (r = 0.67, p = 0.59), IVRT (r = -0.35, p = 0.178), Mitral deceleration time (DT) (r = -0.06, p = 0.842), pulmonary venous peak systolic (r = -0.02, p = 0.966) and diastolic flows (r = 0.47, p = 0.201) to LVEDP. There was a good positive correlation between elevated LVEDP and difference in duration of pulmonary venous and mitral flow at atrial contraction (A-Ard) and E/Ea at all four longitudinal segments of the left ventricle. The sensitivity and specificity for detecting an elevated LVEDP of more than 12 mm Hg, using a cut off value of E/Ea< 8, were 89% and 90%.Lateral E/Ea ≥ 12, LAVI ≥34 mL/m2, and Ard-Ad > 30 msec have the greatest diagnostic value for diagnosing diastolic dysfunction in HFpEF patients. CONCLUSION: Lateral E/Ea ≥ 12, LAVI ≥34 mL/m2, and Ard-Ad > 30 msec have the greatest diagnostic value for diagnosing diastolic dysfunction in HFpEF patients and have good correlation with invasively measured LVEDP.
No takes yet. Share an insight, caveat, or question.
Sharma et al. (2021) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=500). Echocardiographic diastolic parameters was evaluated on Correlation between echocardiographic diastolic parameters (Ard-Ad) and invasively measured left ventricular end diastolic pressure (LVEDP) (r = 0.77, p=<0.001). Echocardiographic parameters including lateral E/Ea ≥ 12, LAVI ≥ 34 mL/m2, and Ard-Ad > 30 msec demonstrated strong diagnostic value and positive correlation with invasively measured left ventricular end-diastolic pressure in patients with HFpEF.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: