Key result
Skin microvascular reactivity was negatively correlated with diabetic polyneuropathy severity, with stronger correlations in patients with retinopathy.
Why the study?
Neurogenic regulation is involved in microcirculation response to local heating, suggesting microvascular reactivity might help estimate the severity of diabetic polyneuropathy.
Does skin microvascular reactivity correlate with the severity of diabetic polyneuropathy in patients with diabetes mellitus?
Cross-Sectional (n=26)
Does skin microvascular reactivity correlate with the severity of diabetic polyneuropathy in patients with diabetes mellitus?
Skin microvascular reactivity correlates with the severity of diabetic polyneuropathy, particularly in patients with established microvascular structural disorders like retinopathy.
Answers are grounded in this paper and cite their sources.
Skin microvascular reactivity parameters may aid DPN severity assessment; leaves open clinical utility pending larger validation studies.
BACKGROUND: Neurogenic regulation is involved in the development of microcirculation response to local heating. We suggest that microvascular reactivity can be used to estimate the severity of diabetic polyneuropathy (DPN). OBJECTIVE: To evaluate the prospects for using the parameters of skin microvascular reactivity to determine the severity of DPN. METHODS: 26 patients with diabetes mellitus were included in the study (patients with retinopathy (n = 15), and without retinopathy (n = 11)). The severity of DPN was assessed using Michigan Neuropathy Screening Instrument (MNSI) and Norfolk QOL-DN (NQOLDN). Skin microcirculation was measured by laser Doppler flowmetry with local heating test. RESULTS: There were revealed moderate negative correlations between microvascular reactivity and the severity of DPN (for MNSI (Rs = -0.430), for NQOLDN (Rs = -0.396)). In patients with retinopathy, correlations were stronger than in the general group (for MNSI (Rs = -0.770) and NQOLDN (Rs = -0.636)). No such correlations were found in patients without retinopathy. CONCLUSION: Correlation of the microvascular reactivity and DPN was revealed in patients with registered structural disorders in microvessels (retinopathy). The lack of such correlation in patients without retinopathy may be explained by the intact compensatory mechanisms of microvessels without severe disorders.
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Krasulina et al. (2021) conducted a cross-sectional in Diabetes mellitus (n=26). Skin microvascular reactivity was evaluated on Correlation between microvascular reactivity and severity of diabetic polyneuropathy (assessed by MNSI and NQOLDN) (Rs = -0.430 for MNSI, Rs = -0.396 for NQOLDN). Skin microvascular reactivity was negatively correlated with diabetic polyneuropathy severity, with stronger correlations in patients with retinopathy.
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