Key result
Peripheral diabetic neuropathy was associated with significantly lower microvascular reactivity in type 1 diabetes (PORH(max) 24 vs 64 PU, p<0.001), but no such difference was found in type 2 diabetes.
Why the study?
Is there a difference in the relationship between peripheral diabetic neuropathy and microvascular reactivity in type 1 versus type 2 diabetic patients?
Population
108 participants, including 28 type 1 diabetic patients, 37 type 2 diabetic patients, and 43 age and body…
Design
Cross-sectional
Authors
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Microvascular reactivity differences should not yet guide neuropathy evaluation by diabetes type; hypothesis-generating for type-specific mechanisms.
Cross-Sectional (n=108)
Is there a difference in the relationship between peripheral diabetic neuropathy and microvascular reactivity in type 1 versus type 2 diabetic patients?
Absolute Event Rate: 24% vs 64%
p-value: p=<0.001
The pathogenesis of neuropathy and impaired microvascular reactivity may be differently influenced by metabolic factors in type 1 versus type 2 diabetes, as microvascular reactivity correlates inversely with neuropathy in type 1 but not type 2 diabetes.
Kasalová et al. (2006) conducted a cross-sectional in Type 1 and Type 2 Diabetes Mellitus (n=108). Peripheral diabetic neuropathy vs. Absence of peripheral diabetic neuropathy was evaluated on Peak flow after occlusion (PORH(max)) in type 1 diabetic patients (p=<0.001). Peripheral diabetic neuropathy was associated with significantly lower microvascular reactivity in type 1 diabetes (PORH(max) 24 vs 64 PU, p<0.001), but no such difference was found in type 2 diabetes.
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