What does this research mean for the field?

Microvascular and macrovascular reactivity is significantly reduced, and markers of endothelial activation are elevated, in individuals at risk for type 2 diabetes even while they maintain normal glucose tolerance. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to investigate vascular reactivity in individuals at risk for type 2 diabetes compared to healthy controls.

September 1, 1999Diabetes

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.

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Why the study?

Is vascular reactivity in the micro- and macrocirculation reduced in individuals at risk for developing type 2 diabetes compared to healthy controls?

Key Points

This research aims to investigate vascular reactivity in individuals at risk for type 2 diabetes compared to healthy controls.
Studied four groups: controls, relatives of type 2 diabetes patients, subjects with impaired glucose tolerance, and type 2 diabetes patients.
Measured vascular responses using laser Doppler imaging for microcirculation and ultrasound for macrocirculation.
Analyzed plasma concentrations of endothelial activation markers including ET-1, vWF, sICAM, and sVCAM.
Vasodilatory responses to acetylcholine were significantly reduced in relatives (98 +/- 48), IGT (94 +/- 52), and diabetes (74 +/- 45) compared to controls (126 +/- 67, P < 0.001).
Responses to sodium nitroprusside also decreased: controls (123 +/- 46), relatives (85 +/- 46), IGT (83 +/- 48), and diabetes (65 +/- 31, P < 0.001).
Brachial artery diameter changes during reactive hyperemia were lower in all groups compared to controls (P < 0.01), with significant correlations observed with various health indicators.

Structured PICO

Is vascular reactivity in the micro- and macrocirculation reduced in individuals at risk for developing type 2 diabetes compared to healthy controls?

Population

143 subjects divided into four age and sex comparable groups: 30 healthy normoglycemic subjects with no history of type 2 diabetes in a first-degree relative (controls), 39 healthy normoglycemic subjects with a history of type 2 diabetes in one or both parents (relatives), 32 subjects with impaired glucose tolerance (IGT), and 42 patients with type 2 diabetes without vascular complications.

Comparator

Healthy normoglycemic subjects with no history of type 2 diabetes in a first-degree relative (controls)

Outcome

Vasodilation in the forearm skin in response to iontophoresis of 1% acetylcholine chloride (Ach) and 1% sodium nitroprusside (SNP), and brachial artery diameter changes during reactive hyperemiasurrogate

Abnormalities in vascular reactivity and biochemical markers of endothelial cell activation are present early in individuals at risk of developing type 2 diabetes, even when normal glucose tolerance exists.

Discussion

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Implication

Reduced vascular reactivity may precede diabetes; extends established diabetes findings to at-risk relatives and IGT but remains hypothesis-generating.

Cite This Study

Caballero et al. (1999) studied this question.

synapsesocial.com/papers/6a1bd52f01af05bf0da8f5c0 https://doi.org/10.2337/diabetes.48.9.1856

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Implication

Reduced vascular reactivity may precede diabetes; extends established diabetes findings to at-risk relatives and IGT but remains hypothesis-generating.

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider