Key result
Healthy middle-aged individuals with reduced flow-mediated dilation (<5%) exhibited a significantly reduced baseline-corrected microvascular arterial dilation response to flickering light (p=0.039).
Why the study?
To investigate microvascular function in apparently healthy individuals showing signs of early macrovascular endothelial dysfunction.
Does a reduced macrovascular flow-mediated dilation response correlate with impaired microvascular function in healthy middle-aged individuals?
Cross-Sectional (n=100)
Does a reduced macrovascular flow-mediated dilation response correlate with impaired microvascular function in healthy middle-aged individuals?
p-value: p=0.039
In healthy middle-aged individuals, early signs of macrovascular endothelial dysfunction are associated with simultaneous microvascular dysfunction.
Concurrent macro- and microvascular endothelial dysfunction suggested in healthy adults; hypothesis-generating and should not yet change practice.
Aims: To investigate the microvascular function in apparently healthy individuals showing signs of early macrovascular endothelial dysfunction. Methods: Healthy participants aged between 30−55 years were recruited for the present study. Baseline measurements included body-mass index (BMI), waist-to-hip ratio (WHR), 24-h blood pressure, as well as fasted venous glucose, triglycerides (TG) and cholesterol (HDL, LDL and total). Brachial artery reactivity was measured using the flow-mediated dilation (FMD) technique and retinal vessel reactivity was assessed by using the Dynamic Retinal Vessel Analyser (DVA) in all individuals. The enrolled participants were separated in two groups, based on either a reduced (group 1: <5%—n = 53) or a normal FMD response (group 2: 7−10%—n = 47). Results: Individuals exhibiting reduced FMD responses showed a reduced baseline-corrected microvascular arterial dilation response to flickering light (p = 0.039). In addition, they also exhibited a reduced arteriolar maximum dilation (p = 0.034), as well as a longer dilation reaction time (p = 0.048) and a lower dilation amplitude (p = 0.042) when compared to those with normal FMD values. Conclusion: In otherwise healthy middle-aged individuals, early signs of vascular dysfunction are reflected simultaneously at both macro- and microvascular levels.
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Patel et al. (2022) conducted a cross-sectional in Healthy individuals with low cardiovascular disease risk (n=100). Reduced flow-mediated dilation (FMD) response (<5%) vs. Normal FMD response (7-10%) was evaluated on Baseline-corrected microvascular arterial dilation response to flickering light (p=0.039). Healthy middle-aged individuals with reduced flow-mediated dilation (<5%) exhibited a significantly reduced baseline-corrected microvascular arterial dilation response to flickering light (p=0.039).
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