Why the study?
Are skin microvascular function and hemostatic markers of endothelial injury altered in patients with NIDDM compared to healthy controls?
Population
54 patients with non-insulin-dependent diabetes mellitus and 38 sex- and age-matched controls.
Design
Cross-sectional
Authors
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Microvascular dysfunction in type 2 diabetes may precede hemostatic marker changes; hypothesis-generating for early endothelial injury but requires prospective validation.
Are skin microvascular function and hemostatic markers of endothelial injury altered in patients with NIDDM compared to healthy controls?
In patients with type 2 diabetes, microvascular endothelial dysfunction occurs independently of overt vascular complications and is not necessarily associated with increased circulating hemostatic markers of endothelial damage.
Bernard Waeber (2008) studied this question.
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