Key result
Type 1 diabetes was associated with reduced peak capillary blood cell velocity compared to controls (0.69 vs 0.96 mm/s, p<0.05) and prolonged time to peak (33.8 vs 13.6 s, p<0.001).
Why the study?
Does skin microcirculation impairment differ between type 1 and type 2 diabetic patients based on metabolic control and disease duration?
Population
70 subjects: 16 type 1 diabetic patients, 19 type 2 diabetic patients, and 35 age- and sex-matched…
Comparison
Assessment of skin microcirculation using laser… vs Age- and sex-matched non-diabetic controls
Design
Case-control
Authors
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Skin microcirculation impairment appears early in type 1 diabetes; leaves open differential roles of HbA1c versus duration in type 2.
Observational (n=70)
Does skin microcirculation impairment differ between type 1 and type 2 diabetic patients based on metabolic control and disease duration?
Absolute Event Rate: 0.69% vs 0.96%
p-value: p=<0.05
Skin capillary circulation is impaired within the first 10 years of both diabetes types, but actual metabolic control (HbA1c) appears more critical for microvascular dysfunction in type 2 than in type 1 diabetes.
Meyer et al. (2009) conducted an observational in Diabetes (Type 1 and Type 2) (n=70). Diabetes (Type 1 and Type 2) vs. Age- and sex-matched non-diabetic subjects was evaluated on Peak capillary blood cell velocity (CBV) after 3-min arterial occlusion in type 1 diabetic patients (p=<0.05). Type 1 diabetes was associated with reduced peak capillary blood cell velocity compared to controls (0.69 vs 0.96 mm/s, p<0.05) and prolonged time to peak (33.8 vs 13.6 s, p<0.001).
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