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April 16, 2023MedicinaOpen Access

Reactive hyperemia measured using peripheral arterial tonometry (PAT) may reflect diabetic neuropathic changes with greater sensitivity compared to flow-mediated dilation (FMD), which showed no significant differences between diabetics with and without CAN.

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Why the study?

The study aimed to determine the relationship between the autonomic nervous system and reactive hyperemia in type 2 diabetes patients with and without cardiovascular autonomic neuropathy.

Is reactive hyperemia altered in type 2 diabetes patients with cardiovascular autonomic neuropathy compared to those without?

Population

Type 2 diabetes patients with and without cardiovascular autonomic neuropathy and healthy controls across included studies

Comparison

Reactive hyperemia and autonomic activity in patients with vs without cardiovascular autonomic neuropathy and healthy controls

Design

Systematic review of randomized and nonrandomized clinical studies

Authors

ELErislandis López-GalánAMArquímedes Montoya-PedrónRBRafael Barrio-Deler

Discussion

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Member takes

Overview

RH differences may aid CAN screening in T2DM; confirms autonomic-vascular link and extends evidence to neuropathy subgroups.

Structured PICO

Is reactive hyperemia altered in type 2 diabetes patients with cardiovascular autonomic neuropathy compared to those without?

P
Population
Type 2 diabetes patients with and without cardiovascular autonomic neuropathy (CAN), and healthy controls
I
Intervention
Measurement of reactive hyperemia (using peripheral arterial tonometry [PAT], flow-mediated dilation [FMD], or laser Doppler)
C
Comparator
Healthy controls or diabetic patients without CAN
O
Outcome
Reactive hyperemia response / endothelial functionsurrogate

In patients with type 2 diabetes, reactive hyperemia measured by peripheral arterial tonometry is more sensitive than flow-mediated dilation for detecting microvascular alterations associated with cardiovascular autonomic neuropathy.

Cite This Study

López-Galán et al. (2023) studied this question.

synapsesocial.com/papers/6a729faa35aa2c282ce35954https://doi.org/10.3390/medicina59040770
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autonomic cardiovascular changes during reactive hyperemia2026
  2. 2Determinants of post‐ischaemic reactive hyperaemia in patients with diabetes mellitus type II1999 · 5 citations
  3. 3Relationship Between Peripheral Diabetic Neuropathy and Microvascular Reactivity in Patients with Type 1 and Type 2 Diabetes Mellitus2006 · 25 citations
  4. 4Effects of Autonomic Neuropathy on Coronary Blood Flow in Patients With Diabetes Mellitus1999 · 248 citations
  5. 5Peripheral sensory neuropathy is associated with altered postocclusive reactive hyperemia in the diabetic foot2016 · 26 citations