Key result
Genetically altered animal models have confirmed an important role of the kallikrein-kinin system in cardiovascular pathology, inflammation, and pain.
Population
Genetically altered animal models (rats and mice) of the kallikrein-kinin system
Design
Review
Authors
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May inform kallikrein-kinin system-targeted trials; leaves open clinical translation in cardiovascular pathology.
This review highlights how genetically altered animal models have elucidated the role of the kallikrein-kinin system in cardiovascular pathology and inflammation, providing a basis for therapeutic applications.
Pesquero et al. (2006) conducted a review in Cardiovascular pathology, inflammation, and pain. Genetically altered animal models (kallikrein-kinin system) was evaluated. Genetically altered animal models have confirmed an important role of the kallikrein-kinin system in cardiovascular pathology, inflammation, and pain.