Key result
Higher 24-hour diastolic average real variability was significantly associated with cerebral white matter hyperintensity progression over 2 years (β = 0.144; 95% CI 0.030-0.258).
Why the study?
Blood pressure variability is linked to cerebral white matter hyperintensities, but longitudinal studies assessing progression are scarce.
Are 24-hour blood pressure variability and nocturnal dipping associated with the prevalence and progression of cerebral white matter hyperintensities?
Cohort (n=177)
Are 24-hour blood pressure variability and nocturnal dipping associated with the prevalence and progression of cerebral white matter hyperintensities?
Effect estimate: β = 0.144 (95% CI 0.030-0.258)
Absent diastolic nocturnal dipping and higher 24-hour diastolic blood pressure variability are associated with greater cerebral white matter hyperintensity volume and progression, suggesting blood pressure patterns may be a target to prevent small vessel disease.
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May inform risk stratification in CVD; extends cross-sectional data but leaves open whether targeting BPV slows WMH progression.
Starmans et al. (2023) conducted a cohort in Cardiovascular disease (n=177). Blood pressure variability and nocturnal dipping was evaluated on Cerebral white matter hyperintensities (WMH) progression (β = 0.144, 95% CI 0.030-0.258). Higher 24-hour diastolic average real variability was significantly associated with cerebral white matter hyperintensity progression over 2 years (β = 0.144; 95% CI 0.030-0.258).
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