Key result
Abnormal blood pressure variability was significantly associated with male gender, mild to moderate hypertension, diabetes, non-dipping, and beta-blocker use in patients with essential hypertension.
Why the study?
Blood pressure variability in hypertensive patients leads to additional cardiovascular complications, but its determinants among patients with essential hypertension required identification.
Cross-Sectional (n=114)
No
Blood pressure variability in essential hypertension is significantly associated with factors such as male gender, diabetes, higher BMI, and beta-blocker use, suggesting these should be considered in comprehensive hypertension management.
May inform BPV assessment in hypertension; leaves open causal links and outcome impact.
Background: Blood pressure variability (BPV) in hypertensive patients is implicated as a remarkable feature leading to additional cardiovascular complications. The aim of the study was to identify the determinants influencing BPV among patients with essential hypertension seen at the Cardiology department of the faculty of medicine, University of Alexandria, Egypt. Methods: This was a descriptive cross-sectional hospital-based study conducted from August 2019 to November 2019. All the eligible patients were made to fill out a standard questionnaire to obtain family and personal clinical history and undergo routine physical examination, laboratory tests and 24-hour ambulatory blood pressure monitoring. BPV was summarized as the standard deviation (SD) of all-day systolic and diastolic BP in both normal patients (with SD 11) and abnormal patients (with SD ≥ 11). Results: Out of a total of 114 patients, 18 (15.8%) non-hypertensive patients were included in the control group and the remaining 96 (84.3%) were classified based on the degree of hypertension. BPV in all these patients was found to be significantly related to the male gender, a mild or moderate degree of hypertension, high prevalence of non-dipping, diabetes, use of beta-blockers as antihypertensive medication, heart rate variability, BMI, and increased day-time variability. Conclusion: Variability in blood pressure influenced by different intrinsic and extrinsic factors plays an important role in the management of hypertension. In order to reduce the burden of disease and for a better quality of life for hypertensive patients, it is important that physicians start considering lowering BPV in addition to reducing physiological BP levels.
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Amr Kamal (2022) conducted a cross-sectional in Essential hypertension (n=114). Clinical and demographic factors (gender, hypertension severity, diabetes, medications) vs. Patients without these factors was evaluated on Abnormal blood pressure variability (standard deviation ≥ 11 mmHg). Abnormal blood pressure variability was significantly associated with male gender, mild to moderate hypertension, diabetes, non-dipping, and beta-blocker use in patients with essential hypertension.
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