What does this research mean for the field?

Although increased blood pressure variability is associated with a higher incidence of cardiovascular complications, it does not hold independent prognostic significance when adjusting for associated factors such as age, diabetes, and average blood pressure. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to evaluate how blood pressure variability impacts cardiovascular health in individuals with essential hypertension.

April 1, 1996American Journal of Hypertension

Prognostic significance of blood pressure variability in essential hypertension.

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Why the study?

Does high blood pressure variability independently predict cardiovascular morbid events in individuals with essential hypertension?

Population

1372 individuals with essential hypertension whose initial off-therapy diagnostic work-up included 24 h…

Comparison

High blood pressure variability vs Low blood pressure variability

Design

Cohort

Follow-up

up to 8.6 years (mean 2.92)

Authors

PVPaolo VerdecchiaPreventive Cardiology

Discussion

Member takes

Implication

Blood pressure variability should not yet guide risk stratification in essential hypertension; leaves open independent prognostic value beyond average nighttime pressure.

Key Points

This research aims to evaluate how blood pressure variability impacts cardiovascular health in individuals with essential hypertension.
Followed 1372 individuals with essential hypertension for an average of 2.92 years, monitoring blood pressure non-invasively.
Classified subjects into low and high blood pressure variability based on their 24-hour ambulatory readings.
Performed repeated echocardiography on 182 participants after 2.7 years to assess heart changes.
Participants with high daytime systolic blood pressure variability showed greater target organ damage scores (P=0.004).
During follow-up, major cardiovascular morbid events were higher in participants with high blood pressure variability (1.99 vs 3.26 events per 100 patient-years).
Multivariate analysis indicated that blood pressure variability was not independently predictive of cardiovascular events due to the influence of other factors.

Structured PICO

Does high blood pressure variability independently predict cardiovascular morbid events in individuals with essential hypertension?

Population

1372 individuals with essential hypertension whose initial off-therapy diagnostic work-up included 24 h non-invasive ambulatory blood pressure monitoring.

Intervention

High blood pressure variability (standard deviation of daytime or night-time blood pressure above the group mean)

Comparator

Low blood pressure variability (standard deviation of daytime or night-time blood pressure below the group mean)

Outcome

Incidence of cardiovascular morbid eventshard clinical

Increased blood pressure variability is associated with higher cardiovascular event rates, but this association is not independent of other risk factors such as age, diabetes, and average blood pressure.

Cite This Study

Paolo Verdecchia (1996) studied this question.

synapsesocial.com/papers/6a1931ebff42a97fac57f1d4 https://doi.org/10.1016/0895-7061(96)81482-8

Topics

Hypertension management

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Implication

Blood pressure variability should not yet guide risk stratification in essential hypertension; leaves open independent prognostic value beyond average nighttime pressure.

Prognostic significance of blood pressure variability in essential hypertension.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Prognostic significance of blood pressure variability in essential hypertension.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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