The genesis of arrhythmias during myocardial ischemia. Dissociation between changes in cyclic adenosine monophosphate and electrical instability in the rat.

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Population

Isolated perfused rat hearts subjected to coronary artery occlusion for 30 minutes

Comparison

Epinephrine or forskolin added to perfusion fluid vs Control hearts without added epinephrine or…

Design

Preclinical

Follow-up

30 minutes

Authors

Discussion

Questions cAMP sufficiency for ischemic arrhythmias in animals; challenges mechanistic assumptions and leaves open human translation.

Population

Isolated perfused rat hearts subjected to coronary artery occlusion for 30 minutes

Intervention

Epinephrine (1.0 microM) or forskolin (0.2 microM) added to perfusion fluid

Comparator

Control hearts without added epinephrine or forskolin

Outcome

Incidence of arrhythmias (fibrillation, ventricular tachycardia) and number of premature ventricular complexessurrogate

Increases in tissue cyclic AMP alone are not sufficient to induce early ischemic arrhythmias, dissociating cAMP levels from electrical instability.

Manning et al. (1985) studied this question.

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