Key result
In heart failure patients without baseline LV dyssynchrony, induction of LV dyssynchrony after CRT was an independent predictor of mortality (HR 1.247; P=0.009).
Why the study?
Does cardiac resynchronization therapy increase mortality in heart failure patients without significant baseline LV dyssynchrony?
Does cardiac resynchronization therapy increase mortality in heart failure patients without significant baseline LV dyssynchrony?
Hazard Ratio: 1.247
Absolute Event Rate: 23% vs 10%
p-value: p=0.009
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This editorial highlights that CRT can induce mechanical dyssynchrony in heart failure patients lacking it at baseline, leading to increased mortality and suggesting a need to refine patient selection criteria beyond QRS duration.
Sanderson et al. (2012) conducted an editorial in Heart failure (n=290). Induction of LV dyssynchrony after CRT (≥40 ms) vs. No induced LV dyssynchrony after CRT (<40 ms) was evaluated on Mortality (HR 1.247, p=0.009). In heart failure patients without baseline LV dyssynchrony, induction of LV dyssynchrony after CRT was an independent predictor of mortality (HR 1.247; P=0.009).
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