Key result
Prepacing systolic dyssynchrony measured by tissue Doppler velocity (delay ≥65 ms) predicted lower cardiovascular mortality after CRT (19% vs 38%; HR 0.463; 95% CI 0.270-0.792; P=0.005).
Why the study?
Does prepacing systolic dyssynchrony measured by tissue Doppler velocity versus strain imaging better predict long-term cardiovascular events in patients undergoing CRT?
Cohort (n=239)
Yes
Does prepacing systolic dyssynchrony measured by tissue Doppler velocity versus strain imaging better predict long-term cardiovascular events in patients undergoing CRT?
Hazard Ratio: 0.463 (95% CI 0.27–0.792)
Absolute Event Rate: 19% vs 38%
p-value: p=0.005
Echocardiographic evidence of prepacing systolic dyssynchrony measured by tissue Doppler velocity, but not strain, is a significant predictor of lower long-term cardiovascular events after CRT.
No takes yet. Share an insight, caveat, or question.
Tissue Doppler dyssynchrony may aid CRT response prediction; leaves open whether it outperforms strain imaging or refines selection criteria.
Zhang et al. (2009) conducted a cohort in Patients undergoing cardiac resynchronisation therapy (CRT) (n=239). Systolic dyssynchrony measured by tissue Doppler velocity (maximal delay in Ts ≥65 ms) vs. No systolic dyssynchrony (maximal delay in Ts <65 ms) was evaluated on Cardiovascular mortality (HR 0.463, 95% CI 0.270 to 0.792, p=0.005). Prepacing systolic dyssynchrony measured by tissue Doppler velocity (delay ≥65 ms) predicted lower cardiovascular mortality after CRT (19% vs 38%; HR 0.463; 95% CI 0.270-0.792; P=0.005).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: