What question did this study set out to answer?

To examine how microglial intracellular metabolism and the brain's metabolic microenvironment regulate neuroimmune responses, neuroinflammation, and the pathophysiology of psychiatric disorders.

January 9, 2025AJP Endocrinology and MetabolismOpen Access

Neuroimmunometabolism: how metabolism orchestrates immune response in healthy and diseased brain

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Authors

ARAnil RanaDenali Therapeutics (United States)BBBabita BhattQueen's University Belfast CGChitralekha GusainRegional Centre for Biotechnology

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Implication

Review uncovers how microglial metabolism governs neuroimmune signaling in the brain, suggesting metabolic reprogramming as a potential intervention for psychiatric disorders.

Key Points

To examine how microglial intracellular metabolism and the brain's metabolic microenvironment regulate neuroimmune responses, neuroinflammation, and the pathophysiology of psychiatric disorders.
Literature synthesis assessing immunometabolic substrate balances and microglial metabolism in healthy versus diseased central nervous systems.
Evaluation of neuron-microglia metabolic crosstalk and cellular signaling mechanisms in neuroinflammation and psychiatric pathogenesis.
Microglia dynamically modify their intracellular metabolic pathways in response to substrate availability and neuronal signaling to direct central nervous system immune functions.
Dysregulation of immunometabolic substrates drives aberrant microglial activation and neuroinflammation, contributing to the development of psychiatric conditions.
Reprogramming microglial intracellular metabolism presents a viable preventive and therapeutic target for managing neuroinflammation-driven brain diseases.

Cite This Study

Rana et al. (2025) studied this question.

synapsesocial.com/papers/6a71d44aac440176ef2a5e67 https://doi.org/10.1152/ajpendo.00331.2024

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Implication

Review uncovers how microglial metabolism governs neuroimmune signaling in the brain, suggesting metabolic reprogramming as a potential intervention for psychiatric disorders.

Neuroimmunometabolism: how metabolism orchestrates immune response in healthy and diseased brain

Discussion

Member takes

Implication

Key Points

Cite This Study

Neuroimmunometabolism: how metabolism orchestrates immune response in healthy and diseased brain

Discussion

Member takes

Implication

Key Points

Cite This Study

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