May 19, 2004Nephron Physiology
Urinary Excretion Rate of Tamm-Horsfall Protein Is Related to Salt Intake in Humans
Key result
Low salt intake decreased nocturnal urinary excretion of Tamm-Horsfall protein to 11.7 microg/min vs 19.5 microg/min at baseline (p<0.05) and 23.1 microg/min during high salt intake (p<0.01).
Why the study?
Does salt intake affect the urinary excretion rate of Tamm-Horsfall protein in healthy individuals genetically prone to hypertension?
Population
30 healthy, unrelated subjects with at least one first-degree relative with primary hypertension.
Comparison
Low-salt diet for 1 week, followed by high-salt… vs Baseline diet and intra-individual comparison…
Design
Cohort
Follow-up
2 weeks
Authors
Discussion
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Implication
Low salt intake was associated with reduced nocturnal Tamm-Horsfall protein excretion; hypothesis-generating for salt sensitivity in genetically prone hypertension.
Structured PICO
Does salt intake affect the urinary excretion rate of Tamm-Horsfall protein in healthy individuals genetically prone to hypertension?
P
Population
30 healthy adults with a first-degree relative with primary hypertension underwent sequential 1-week low-salt and high-salt diets.
I
Intervention
Low-salt diet (10 mmol sodium and 70 mmol potassium per day) for 1 week, followed by high-salt diet (240 mmol sodium/day) for 1 week.
C
Comparator
Baseline diet and intra-individual comparison between low and high salt intake periods.
O
Outcome
Urinary excretion rate of Tamm-Horsfall protein (THP).surrogate
Main Result
Absolute Event Rate: 11.7% vs 23.1%
p-value: p=< 0.01
Urinary excretion of Tamm-Horsfall protein is dependent on sodium intake and is more pronounced in salt-sensitive individuals genetically prone to hypertension.
Cite This Study
Torffvit et al. (2004) studied Healthy, genetically hypertension-prone individuals (n=30). Low-salt diet vs. Baseline and high-salt diet (240 mmol/day) was evaluated on Urinary excretion rate of Tamm-Horsfall protein (THP) during the night (p=< 0.01). Low salt intake decreased nocturnal urinary excretion of Tamm-Horsfall protein to 11.7 microg/min vs 19.5 microg/min at baseline (p<0.05) and 23.1 microg/min during high salt intake (p<0.01).